Genesis Mission is a redirection of doe resources towards developing AI technologies for science that was first established by an executive order.
The mission did not come with additional funding, although DOE quickly followed on the announcement by recoloring $320M in funding as being related to Genesis on December 10, 2025.1 That funding package included:2
| Amount | Initiative |
|---|---|
| $40M | American Science Cloud |
| $30M | Transformational AI Model Consortium (fka Trillion Parameter Consortium?) |
| $79M | SciDAC |
| $16M | DIII-D |
A bunch of the above funding predates Genesis, demonstrating that DOE appears to be coloring all of its money as Genesis funding rather than committing new resources to it.
Executive Order details
From LAUNCHING THE GENESIS MISSION:
The Genesis Mission
The Genesis Mission will build an integrated AI platform to harness Federal scientific datasets … to train scientific foundation models and create AI agents to test new hypotheses, automate research workflows, and accelerate scientific breakthroughs.
It establishes the American Science and Security Platform (comically, the ASS Platform) which is the infrastructure that will provide:
- “high-performance computing resources, including DOE national laboratory supercomputers and secure cloud-based AI computing environments, capable of supporting large-scale model training, simulation, and inference;”
- “secure access to appropriate datasets, including proprietary, federally curated, and open scientific datasets, in addition to synthetic data generated through DOE computing resources, consistent with applicable law; applicable classification, privacy, and intellectual property protections”
The Executive Order itself represents a redirection of existing investments rather than net-new investment. For example, it orders that
Directive to identify resources, not buy new ones
the Secretary shall identify Federal computing, storage, and networking resources available to support the Mission, including both DOE on-premises and cloud-based high-performance computing systems, and resources available through industry partners
Emphasis on automation and robotics
review capabilities across the DOE national laboratories and other participating Federal research facilities for robotic laboratories and production facilities with the ability to engage in AI-directed experimentation and manufacturing, including automated and AI-augmented workflows
It specifically prioritizes the following domains and, implicitly, de-emphasizes all basic sciences.
Exemplar science and technology challenges of national importance
(i) advanced manufacturing; (ii) biotechnology; (iii) critical materials; (iv) nuclear fission and fusion energy; (v) quantum information science; and (vi) semiconductors and microelectronics.
There is a strong emphasis on cross-government partnership and private sector as well:
Quote
launch coordinated funding opportunities or prize competitions across participating agencies, to the extent permitted by law and subject to available appropriations, to incentivize private-sector participation in AI-driven scientific research progress toward integration across DOE national laboratories and other participating Federal research partners
I also wrote about the Genesis Mission in my SC’25 recap blog.